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Sequence Information

Primary Database Link B2Z3B1
Original Database ID EN ENSP00000430269.1
Organism Homo sapiens, synthetic construct
Annotation subname: full=epoxide hydrolase
2, cytoplasmic, isoform cra_b;subname:
full=epox ide hydrolase 2, cytoplasmic;
Sequence Length 555

Dataset Information:

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Model Information

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Target Region2-548
Protein Length555
Template PDB Code5ai0A
Template Region2-548
Sequence Identity100%
E-Value0
GA3411
MPQS2.23189
z-DOPE-1.56
TSVMod MethodMSALL
TSVMod RMSD0.491
TSVMod NO350.96
DatasetMW-Human_D15
ModPipe VersionSVN.r1693
Model Date2020-05-15

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Cross-references

Show obsolete/secondary identifiers
Mutation Data
PharmGKB   PharmGKB data available for EPHX2
Template Structure
PDB5ai0
DBALI5ai0A 
JenaImageLibrary5ai0 
Target Sequence
SFLD27597073Structure Function Linkage Database entry: Member of the Haloacid dehalogenase superfamily.
UniProtKBQ9HBJ1RecName: Full=Epoxide hydrolase 2;EC=3.3.2.10;AltName: Full=Cytosolic epoxide hydrolase;Short=CEH;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=SEH;
InterProQ9HBJ1 
PFAMQ9HBJ1 
ProdomQ9HBJ1 
UniProtKBQ9HBJ2RecName: Full=Bifunctional epoxide hydrolase 2;Includes:RecName: Full=Cytosolic epoxide hydrolase 2;Short=CEH;EC=3.3.2.10;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=
InterProQ9HBJ2 
PFAMQ9HBJ2 
ProdomQ9HBJ2 
UniProtKBQ16764RecName: Full=Epoxide hydrolase 2;EC=3.3.2.10;AltName: Full=Cytosolic epoxide hydrolase;Short=CEH;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=SEH;
InterProQ16764 
PFAMQ16764 
ProdomQ16764 
UniProtKBP34913RecName: Full=Epoxide hydrolase 2;EC=3.3.2.10;AltName: Full=Cytosolic epoxide hydrolase;Short=CEH;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=SEH;
InterProP34913 
PFAMP34913 
ProdomP34913 
UniProtKBB2Z3B1RecName: Full=Epoxide hydrolase 2;EC=3.3.2.10;AltName: Full=Cytosolic epoxide hydrolase;Short=CEH;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=SEH;
InterProB2Z3B1 
PFAMB2Z3B1 
ProdomB2Z3B1 
UniProtKBB2Z3B1SubName: Full=Epoxide hydrolase 2, cytoplasmic, isoform CRA_b;SubName: Full=Epoxide hydrolase 2, cytoplasmic;
InterProB2Z3B1 
PFAMB2Z3B1 
ProdomB2Z3B1 
UniProtKBQ16764Epoxide hydrolase 2, cytoplasmic (EC 3.3.2.3) (Soluble epoxideDE hydrolase)
InterProQ16764 
PFAMQ16764 
ProdomQ16764 
UniProtKBQ9HBJ2RecName: Full=Bifunctional epoxide hydrolase 2;Includes:RecName: Full=Cytosolic epoxide hydrolase 2;Short=CEH;EC=3.3.2.10;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=
InterProQ9HBJ2 
PFAMQ9HBJ2 
ProdomQ9HBJ2 
UniProtKBB2Z3B1RecName: Full=Bifunctional epoxide hydrolase 2;Includes:RecName: Full=Cytosolic epoxide hydrolase 2;Short=CEH;EC=3.3.2.10;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=
InterProB2Z3B1 
PFAMB2Z3B1 
ProdomB2Z3B1 
UniProtKBP34913RecName: Full=Bifunctional epoxide hydrolase 2;Includes:RecName: Full=Cytosolic epoxide hydrolase 2;Short=CEH;EC=3.3.2.10;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=
InterProP34913 
PFAMP34913 
ProdomP34913 
UniProtKBP34913.2HYES_HUMAN RecName: Full=Epoxide hydrolase 2; AltName: Full=Cytosolic epoxide hydrolase; Short=CEH; AltName: Full=Epoxide hydratase; AltName: Full=Soluble epoxide hydrolase; Short=SEH
InterProP34913.2 
PFAMP34913.2 
ProdomP34913.2 
UniProtKBQ16764RecName: Full=Bifunctional epoxide hydrolase 2;Includes:RecName: Full=Cytosolic epoxide hydrolase 2;Short=CEH;EC=3.3.2.10;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=
InterProQ16764 
PFAMQ16764 
ProdomQ16764 
UniProtKBQ9HBJ1RecName: Full=Bifunctional epoxide hydrolase 2;Includes:RecName: Full=Cytosolic epoxide hydrolase 2;Short=CEH;EC=3.3.2.10;AltName: Full=Epoxide hydratase;AltName: Full=Soluble epoxide hydrolase;Short=
InterProQ9HBJ1 
PFAMQ9HBJ1 
ProdomQ9HBJ1 
RefSeqNP_001970.2 epoxide hydrolase 2 [Homo sapiens]
PDB3KOOA Chain A, Crystal Structure Of Soluble Epoxide Hydrolase
PDB3I28AChain A, Crystal Structure Of Soluble Epoxide Hydrolase
PDB3I28A Chain A, Crystal Structure Of Soluble Epoxide Hydrolase
PDB3I1YAChain A, Crystal Structure Of Soluble Epoxide Hydrolase
PDB3KOOAChain A, Crystal Structure Of Soluble Epoxide Hydrolase
PDB3OTQAChain A, Soluble Epoxide Hydrolase In Complex With Pyrazole Antagonist
PDB4HAIAChain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With N- Cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.
PDB4J03AChain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With Fulvestrant
PDB4OCZAChain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With 1- (1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
PDB4OD0AChain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With 1- (1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
PDB3I1YA Chain A, Crystal Structure Of Soluble Epoxide Hydrolase
PDB1ZD3AChain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex
PDB1S8OAChain A, Human Soluble Epoxide Hydrolase
PDB1S8OA Chain A, Human Soluble Epoxide Hydrolase
PDB1ZD3A Chain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex
PDB1ZD4A Chain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Hexanoic Acid Complex
PDB1ZD4AChain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Hexanoic Acid Complex
PDB1ZD5A Chain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Heptanoic Acid Complex
PDB1ZD2PChain P, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Ethanoic Acid Complex
PDB1ZD2P Chain P, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Ethanoic Acid Complex
PDB1VJ5AChain A, Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4- Iodophenyl)urea Complex
PDB1ZD5AChain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Heptanoic Acid Complex
PDB1VJ5A Chain A, Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4- Iodophenyl)urea Complex
GenPept93278561A Chain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Heptanoic Acid Complex
GenPept93278560A Chain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Hexanoic Acid Complex
GenPept93278559A Chain A, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Butyric Acid Complex
GenPept93278558P Chain P, Human Soluble Epoxide Hydrolase 4-(3-Cyclohexyluriedo)- Ethanoic Acid Complex
GenPept694270102A Chain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With 1- (1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea
GenPept694270101A Chain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With 1- (1-isobutyrylpiperidin-4-yl)-3-(4-(trifluoromethyl)phenyl)urea
GenPept187473248epoxide hydrolase 2, cytoplasmic
GenPept119583952epoxide hydrolase 2, cytoplasmic, isoform CRA_b
GenPept123984659epoxide hydrolase 2, cytoplasmic
GenPept123998649epoxide hydrolase 2, cytoplasmic, partial
GenPept12734119 epoxide hydrolase 2, cytoplasmic [Homo sapiens]
GenPept1359739epoxide hydrolase
GenPept14043438Epoxide hydrolase 2, cytoplasmic
GenPept14743830 epoxide hydrolase 2, cytoplasmic [Homo sapiens]
GenPept15079619Epoxide hydrolase 2, cytoplasmic
GenPept15530199Epoxide hydrolase 2, cytoplasmic
GenPept67476665HYES_HUMAN RecName: Full=Epoxide hydrolase 2; AltName: Full=Cytosolic epoxide hydrolase; Short=CEH; AltName: Full=Epoxide hydratase; AltName: Full=Soluble epoxide hydrolase; Short=SEH
GenPept649099808EPHX2, partial
GenPept433286811A Chain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With N- Cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.
GenPept261278773A Chain A, Crystal Structure Of Soluble Epoxide Hydrolase
GenPept10197680AF233334_1 soluble epoxide hydrolase
GenPept2135082JC4711 epoxide hydrolase (EC 3.3.2.3) 2, cytosolic - human
GenPept261278772A Chain A, Crystal Structure Of Soluble Epoxide Hydrolase
GenPept353296383Sequence 39 from patent US 8030048
GenPept310689960A Chain A, Soluble Epoxide Hydrolase In Complex With Pyrazole Antagonist
GenPept307684590epoxide hydrolase 2, cytoplasmic, partial
GenPept30582609epoxide hydrolase 2, cytoplasmic
GenPept295321798A Chain A, Crystal Structure Of Soluble Epoxide Hydrolase
GenPept294547300Sequence 1 from patent US 7662910
GenPept27597073 epoxide hydrolase 2 [Homo sapiens]
GenPept48425649A Chain A, Human Soluble Epoxide Hydrolase
GenPept48425923A Chain A, Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4- Iodophenyl)urea Complex
GenPept61362939epoxide hydrolase 2 cytoplasmic
GenPept61362935epoxide hydrolase 2 cytoplasmic
GenPept568528887Sequence 6073 from patent US 8586006
GenPept532876224Sequence 1 from patent US 8476043
GenPept510973647Sequence 1 from patent US 8455652
GenPept510102099A Chain A, Crystal Structure Of Human Soluble Epoxide Hydrolase Complexed With Fulvestrant
GenBankAAG14966.1AF233334_1 soluble epoxide hydrolase [Homo sapiens]
GenBankABM83675.1 epoxide hydrolase 2, cytoplasmic [synthetic construct]
GenBankAAH07708.1 Epoxide hydrolase 2, cytoplasmic [Homo sapiens]
GenBankAAH11628.1 Epoxide hydrolase 2, cytoplasmic [Homo sapiens]
GenBankAAH13874.1 Epoxide hydrolase 2, cytoplasmic [Homo sapiens]
GenBankAAP35531.1 epoxide hydrolase 2, cytoplasmic [Homo sapiens]
GenBankEAW63548.1 epoxide hydrolase 2, cytoplasmic, isoform CRA_b [Homo sapiens]
GenBankAAX42304.1 epoxide hydrolase 2 cytoplasmic [synthetic construct]
GenBankAAX42305.1 epoxide hydrolase 2 cytoplasmic [synthetic construct]
GenBankACD11487.1 epoxide hydrolase 2, cytoplasmic [Homo sapiens]
GenBankABM86963.1 epoxide hydrolase 2, cytoplasmic [synthetic construct]
ENSEMBLENSP00000315621Soluble epoxide hydrolase (SEH) (EC 3.3.2.3) (Epoxide hydratase) (Cytosolic epoxide hydrolase) (CEH). [Homo sapiens]
EMBLCAA65751.1 
ENSEMBLENSP00000315621 
ENSEMBLENSP00000315621TDI sequence
ENSEMBLENSP00000430269