University of California San Francisco | About UCSF | UCSF Benioff Children's Hospital San Francisco

ModBase: Database of Comparative Protein Structure Models

Model Details Page: SNP Information

Sequence Information

Primary Database Link P33981
Original Database ID SN P33981_chr6:80772328
Organism Homo sapiens
Annotation dual specificity protein kinase
ttk (ec 2.7.12.1) (phosphotyrosinepicked
threoni ne-protein kinase) (pyt)
Sequence Length 841
 

SNP Information

Perform action on this model:

 
 
SNP ViewGenome
Browser
ResidueAA-Residue
Variants
InterfaceLigandStabilityValidated
rs2230512 D742 DN   X
rs17849351 P773 PQH  
rs17254438 P773 PQH  
5 SNPs found but only 3 displayed. (SNPs in modeled regions)
 

Sequence Model Coverage summary
for all models of this sequence

Filtered models for current sequence (Show all models)

 

Cross-references

Show obsolete/secondary identifiers
Mutation Data
LS-Mut Somatic mutation found in advanced pancreatic tumor for CCDS4993.1 D697Y
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB1omwcrystal structure of the complex between g protein-coupled receptor kinase 2 and heterotrimeric g protein beta 1 and gamma 2 subunits ; EC: 2.7.1.126 ; PFAM: PF00069 PF00169 PF00400 PF00615 PF00631
DBALI1omwA 
CATH1.10.167.10 Domain: 1omwA02 Regulator of G-protein Signalling 4, domain 2 (100%)
CATH3.30.200.20 Domain: 1omwA03 Phosphorylase Kinase; domain 1 (46%)
CATH1.10.510.10 Domain: 1omwA04 Transferase(Phosphotransferase) domain 1 (90%)
JenaImageLibrary1omw 
Target Sequence
UniProtKBP33981Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosinepicked threonine-protein kinase) (PYT)
InterProP33981 
PFAMP33981 
ProdomP33981 
GenPept228211900Sequence 14 from patent US 7501242
GenPept228211938Sequence 14 from patent US 7501243
GenPept228211976Sequence 14 from patent US 7501244
GenPept330463742Sequence 14 from patent US 7867731
GenPept340011kinase
GenPept4507719 TTK protein kinase [Homo sapiens]
GenPept464971TTK_HUMAN DUAL SPECIFICITY PROTEIN KINASE TTK (PYT)
GenBankAAA61239.1 kinase [Homo sapiens]
UCSCGenomeBrowserP33981