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ModBase: Database of Comparative Protein Structure Models

Model Details Page: SNP Information

Sequence Information

Primary Database Link A8K3Y9
Original Database ID sp O96017
Organism Pan troglodytes, Homo sapiens, etc.
Annotation subname: full=cdna flj75391, highly
similar to homo sapiens chk2 checkpoint
homo log (s. pombe) (chek2), transcriptvariant
1, mrna;subname: full=chk2 ...
Sequence Length 543
 

SNP Information

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SNP ViewGenome
Browser		ResidueAA-Residue
Variants		InterfaceLigandStabilityValidated
rs17883172 E501 EK  
rs28909981 S500 SC  
rs17886163 I448 IS  
rs17881473 F447 FI  
rs17880867 N446 NK  
rs17882922 L436 LM  
rs28909980 D347 DN  
rs17879961 I157 IT   X
rs28909982 R117 RG   *
11 SNPs found but only 9 displayed. (SNPs in modeled regions)
 

Sequence Model Coverage summary
for all models of this sequence

Cross-references

Show obsolete/secondary identifiers
Mutation Data
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB3i6ustructure and activation mechanism of the chk2 dna-damage checkpoint kinase
DBALI3i6uA 
JenaImageLibrary3i6u 
Target Sequence
UniProtKBQ9UGF1RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=CHK2 checkpoint homolog;AltName: Full=Cds1 homolog;Short=Hucds1;Short=hCds1;AltName: Full=Checkpoint kinase 2;
InterProQ9UGF1 
PFAMQ9UGF1 
ProdomQ9UGF1 
UniProtKBQ9UGF0RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=CHK2 checkpoint homolog;AltName: Full=Cds1 homolog;Short=Hucds1;Short=hCds1;AltName: Full=Checkpoint kinase 2;
InterProQ9UGF0 
PFAMQ9UGF0 
ProdomQ9UGF0 
UniProtKBK7D8Y1SubName: Full=CHK2 checkpoint homolog {ECO:0000313|EMBL:JAA34590.1};
InterProK7D8Y1 
PFAMK7D8Y1 
ProdomK7D8Y1 
UniProtKBQ9HCQ8RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=CHK2 checkpoint homolog;AltName: Full=Cds1 homolog;Short=Hucds1;Short=hCds1;AltName: Full=Checkpoint kinase 2;
InterProQ9HCQ8 
PFAMQ9HCQ8 
ProdomQ9HCQ8 
UniProtKBA8K3Y9SubName: Full=cDNA FLJ75391, highly similar to Homo sapiens CHK2 checkpoint homolog (S. pombe) (CHEK2), transcriptvariant 1, mRNA;SubName: Full=CHK2 checkpoint homolog (S. pombe), isoform CRA_b;
InterProA8K3Y9 
PFAMA8K3Y9 
ProdomA8K3Y9 
UniProtKBO96017Serine/threonine-protein kinase Chk2 (EC 2.7.1.37) (Cds1)
InterProO96017 
PFAMO96017 
ProdomO96017 
UniProtKBQ6QA11RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=Cds1;
InterProQ6QA11 
PFAMQ6QA11 
ProdomQ6QA11 
UniProtKBQ6QA12RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=Cds1;
InterProQ6QA12 
PFAMQ6QA12 
ProdomQ6QA12 
UniProtKBQ6QA13RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=Cds1;
InterProQ6QA13 
PFAMQ6QA13 
ProdomQ6QA13 
UniProtKBO96017.1CHK2_HUMAN RecName: Full=Serine/threonine-protein kinase Chk2; AltName: Full=Cds1
InterProO96017.1 
PFAMO96017.1 
ProdomO96017.1 
UniProtKBQ9UGF0RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=CHK2 checkpoint homolog;AltName: Full=Cds1 homolog;Short=Hucds1;Short=hCds1;AltName: Full=Checkpoint kinase 2;
InterProQ9UGF0 
PFAMQ9UGF0 
ProdomQ9UGF0 
UniProtKBQ9UGF1RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=CHK2 checkpoint homolog;AltName: Full=Cds1 homolog;Short=Hucds1;Short=hCds1;AltName: Full=Checkpoint kinase 2;
InterProQ9UGF1 
PFAMQ9UGF1 
ProdomQ9UGF1 
UniProtKBQ9HCQ8RecName: Full=Serine/threonine-protein kinase Chk2;EC=2.7.11.1;AltName: Full=CHK2 checkpoint homolog;AltName: Full=Cds1 homolog;Short=Hucds1;Short=hCds1;AltName: Full=Checkpoint kinase 2;
InterProQ9HCQ8 
PFAMQ9HCQ8 
ProdomQ9HCQ8 
RefSeqXP_034804396.1serine/threonine-protein kinase Chk2 isoform X5
RefSeqNP_009125.1 serine/threonine-protein kinase Chk2 isoform a [Homo sapiens]
GenPept158254944unnamed protein product
GenPept9927719unnamed protein product
GenPept915739107Sequence 1438 from patent US 8999633
GenPept77364771Sequence 2 from patent US 6943013
GenPept756656063Sequence 9 from patent US 8791112
GenPept6685284CHK2_HUMAN RecName: Full=Serine/threonine-protein kinase Chk2; AltName: Full=Cds1
GenPept649151527CHEK2, partial
GenPept55660842CHK2 checkpoint homolog (S. pombe)
GenPept55140704CHK2 checkpoint homolog (S. pombe)
GenPept4206721HuCds1 kinase
GenPept4007566protein kinase
GenPept3982840protein kinase Chk2
GenPept217100068Sequence 2 from patent US 7414020
GenPept17485110 (XM_037882) CHK2 (checkpoint, S.pombe) homolog [Homo sapiens]
GenPept14778015 protein kinase Chk2 [Homo sapiens]
GenPept13278894CHK2 checkpoint homolog (S. pombe)
GenPept123999807CHK2 checkpoint homolog (S. pombe), partial
GenPept123992914CHK2 checkpoint homolog (S. pombe)
GenPept119580159CHK2 checkpoint homolog (S. pombe), isoform CRA_b
GenPept10044842unnamed protein product
GenPept6005850 serine/threonine-protein kinase Chk2 isoform a [Homo sapiens]
GenPept5726657AF174135_1 protein kinase CHK2
GenPept568596760Sequence 17 from patent US 8597902
GenPept568535670Sequence 25499 from patent US 8586006
GenPept55660889CHK2 checkpoint homolog (S. pombe)
GenBankEAW59755.1 CHK2 checkpoint homolog (S. pombe), isoform CRA_b [Homo sapiens]
GenBankAAC83693.1 protein kinase Chk2 [Homo sapiens]
GenBankAAD11784.1 HuCds1 kinase [Homo sapiens]
GenBankAAD48504.1AF174135_1 protein kinase CHK2 [Homo sapiens]
GenBankAAH04207.1 CHK2 checkpoint homolog (S. pombe) [Homo sapiens]
GenBankAAV41895.1 CHK2 checkpoint homolog (S. pombe) [Homo sapiens]
GenBankABM84059.1 CHK2 checkpoint homolog (S. pombe) [synthetic construct]
GenBankABM87412.1 CHK2 checkpoint homolog (S. pombe) [synthetic construct]
ENSEMBLENSP00000329178Serine/threonine-protein kinase Chk2 (EC 2.7.1.37) (Cds1). [Homo sapiens]
EMBLCAA10319.1 
EMBLCAH73823.1 
EMBLCAH73875.1 
ENSEMBLENSP00000329178 
ENSEMBLENSP00000329178TDI sequence
ENSEMBLENSP00000385747 
UCSCGenomeBrowserO96017