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ModBase: Database of Comparative Protein Structure Models

Model Details Page: SNP Information

Sequence Information

Primary Database Link P08922
Original Database ID gi 337481
Organism Homo sapiens
Annotation proto-oncogene tyrosine-protein
kinase ros precursor (ec 2.7.10.1)
(c-de ros-1 )
Sequence Length 2347
 

SNP Information

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SNP ViewGenome
Browser		ResidueAA-Residue
Variants		InterfaceLigandStabilityValidated
rs529038 N2213 ND   X
rs3752566 R2039 RH   X
rs9489124 E1902 EK  
rs12664076 D1776 DH   C
11 SNPs found but only 4 displayed. (SNPs in modeled regions)
 

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Cross-references

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Mutation Data
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB1qcfcrystal structure of hck in complex with a src family-selective tyrosine kinase inhibitor ; EC: 2.7.1.112 ; PFAM: PF00017 PF00018 PF00069 ; SCOP: 24498 40490 41680
DBALI1qcfA 
CATH2.30.30.40 Domain: 1qcfA01 SH3 Domains (83%)
CATH3.30.505.10 Domain: 1qcfA02 SHC Adaptor Protein (100%)
CATH3.30.200.20 Domain: 1qcfA03 Phosphorylase Kinase; domain 1 (100%)
CATH1.10.510.10 Domain: 1qcfA04 Transferase(Phosphotransferase) domain 1 (100%)
JenaImageLibrary1qcf 
Target Sequence
UniProtKBP08922Proto-oncogene tyrosine-protein kinase ROS precursor (EC 2.7.10.1) (c-DE ros-1)
InterProP08922 
PFAMP08922 
ProdomP08922 
GenPept2506798KROS_HUMAN PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS PRECURSOR
GenPept337481transmembrane tyrosine-specific protein kinase precursor
GenPept4506579 v-ros avian UR2 sarcoma virus oncogene homolog 1; Avian UR2 sarcoma virus oncogene (v-ros) homolog 1 [Homo sapiens]
GenPept507846788Sequence 7 from patent US 8383799
GenBankAAA60278.1 transmembrane tyrosine-specific protein kinase precursor [Homo sapiens]
UCSCGenomeBrowserP08922