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ModBase: Database of Comparative Protein Structure Models

Model Details Page: SNP Information

Sequence Information

Primary Database Link Q96T22
Original Database ID EN ENSP00000412523.2
Organism Gorilla gorilla gorilla, Homo sapiens
Annotation recname: full=caspase-8;short=casp-8;ec=3.4.22.61;altname:
full=apoptotic cystei ne protease;altname:
full=apoptotic protease mch-5;altname:
full=cap4 ...
Sequence Length 479
 

SNP Information

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SNP ViewGenome
Browser		ResidueAA-Residue
Variants		InterfaceLigandStabilityValidated
rs17860424 R248 RW  
rs1045485 D285 DH   X
rs17860425 D285 DH  

Sequence Model Coverage summary
for all models of this sequence

Cross-references

Show obsolete/secondary identifiers
Mutation Data
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB6px9
DBALI6px9A 
JenaImageLibrary6px9 
Target Sequence
UniProtKBQ9UQ81RecName: Full=Caspase-8;Short=CASP-8;EC=3.4.22.61;AltName: Full=Apoptotic cysteine protease;AltName: Full=Apoptotic protease Mch-5;AltName: Full=CAP4;AltName: Full=FADD-homologous ICE/ced-3-like prote
InterProQ9UQ81 
PFAMQ9UQ81 
ProdomQ9UQ81 
UniProtKBQ9C0K4RecName: Full=Caspase-8;Short=CASP-8;EC=3.4.22.61;AltName: Full=Apoptotic cysteine protease;AltName: Full=Apoptotic protease Mch-5;AltName: Full=CAP4;AltName: Full=FADD-homologous ICE/ced-3-like prote
InterProQ9C0K4 
PFAMQ9C0K4 
ProdomQ9C0K4 
UniProtKBQ96T22RecName: Full=Caspase-8;Short=CASP-8;EC=3.4.22.61;AltName: Full=Apoptotic cysteine protease;AltName: Full=Apoptotic protease Mch-5;AltName: Full=CAP4;AltName: Full=FADD-homologous ICE/ced-3-like prote
InterProQ96T22 
PFAMQ96T22 
ProdomQ96T22 
UniProtKBA0A2I2YHY1SubName: Full=Caspase 8 {ECO:0000313|Ensembl:ENSGGOP00000034498}
InterProA0A2I2YHY1 
PFAMA0A2I2YHY1 
ProdomA0A2I2YHY1 
UniProtKBQ14793Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProQ14793 
PFAMQ14793 
ProdomQ14793 
UniProtKBQ14792Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProQ14792 
PFAMQ14792 
ProdomQ14792 
UniProtKBQ14791Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProQ14791 
PFAMQ14791 
ProdomQ14791 
UniProtKBQ14790.1CASP8_HUMAN RecName: Full=Caspase-8; Short=CASP-8; AltName: Full=Apoptotic cysteine protease; AltName: Full=Apoptotic protease Mch-5; AltName: Full=CAP4; AltName: Full=FADD-homologous ICE/ced-3-like p
InterProQ14790.1 
PFAMQ14790.1 
ProdomQ14790.1 
UniProtKBO14676Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProO14676 
PFAMO14676 
ProdomO14676 
UniProtKBQ14794Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProQ14794 
PFAMQ14794 
ProdomQ14794 
UniProtKBQ14795Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProQ14795 
PFAMQ14795 
ProdomQ14795 
UniProtKBQ14796Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProQ14796 
PFAMQ14796 
ProdomQ14796 
UniProtKBQ15780Caspase-8 {ECO:0000303|PubMed:12010809}Short=CASP-8 {ECO:0000303|PubMed:12010809}EC=3.4.22.61 {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:8962078}AltName: Full=Apoptotic cysteine proteaseAltName:
InterProQ15780 
PFAMQ15780 
ProdomQ15780 
UniProtKBQ15806Caspase-8 precursor (EC 3.4.22.-) (ICE-like apoptotic protease 5)DE (MORT1-associated CED-3 homolog) (MACH) (FADD-homo
InterProQ15806 
PFAMQ15806 
ProdomQ15806 
UniProtKBQ96T22RecName: Full=Caspase-8;Short=CASP-8;EC=3.4.22.61;AltName: Full=Apoptotic cysteine protease;AltName: Full=Apoptotic protease Mch-5;AltName: Full=CAP4;AltName: Full=FADD-homologous ICE/ced-3-like prote
InterProQ96T22 
PFAMQ96T22 
ProdomQ96T22 
UniProtKBQ9C0K4RecName: Full=Caspase-8;Short=CASP-8;EC=3.4.22.61;AltName: Full=Apoptotic cysteine protease;AltName: Full=Apoptotic protease Mch-5;AltName: Full=CAP4;AltName: Full=FADD-homologous ICE/ced-3-like prote
InterProQ9C0K4 
PFAMQ9C0K4 
ProdomQ9C0K4 
UniProtKBQ9UQ81RecName: Full=Caspase-8;Short=CASP-8;EC=3.4.22.61;AltName: Full=Apoptotic cysteine protease;AltName: Full=Apoptotic protease Mch-5;AltName: Full=CAP4;AltName: Full=FADD-homologous ICE/ced-3-like prote
InterProQ9UQ81 
PFAMQ9UQ81 
ProdomQ9UQ81 
RefSeqNP_001358980.1caspase-8 isoform B
RefSeqNP_203519.1 caspase-8 isoform B precursor [Homo sapiens]
GenPept756950722Sequence 484 from patent US 8865653
GenPept314514985Sequence 7 from patent US 7799901
GenPept311461888unnamed protein product
GenPept2493531CASP8_HUMAN RecName: Full=Caspase-8; Short=CASP-8; AltName: Full=Apoptotic cysteine protease; AltName: Full=Apoptotic protease Mch-5; AltName: Full=CAP4; AltName: Full=FADD-homologous ICE/ced-3-like p
GenPept2440071MACH-alpha-1
GenPept217116359Sequence 6 from patent US 7419804
GenPept21516674Sequence 7 from patent US 6399327
GenPept197055191Sequence 6 from patent US 7407771
GenPept15718706 caspase-8 isoform B precursor [Homo sapiens]
GenPept14731659 caspase 8, apoptosis-related cysteine protease [Homo sapiens]
GenPept14731648 caspase 8, apoptosis-related cysteine protease [Homo sapiens]
GenPept33752626Sequence 7 from patent US 6586571
GenPept397146720Sequence 349 from patent US 8211428
GenPept757280398Sequence 349 from patent US 8663633
GenPept756818694Sequence 484 from patent US 8828944
GenPept14271066unnamed protein product
GenPept756726325Sequence 5 from patent US 8809002
GenPept756521831Sequence 229 from patent US 8741556
GenPept59719985Sequence 101 from patent US 6833248
GenPept568535855Sequence 26345 from patent US 8586006
GenPept544090406Sequence 65 from patent US 8530168
ENSEMBLENSP00000307131Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine
ENSEMBLENSP00000344731Caspase-8 precursor (EC 3.4.22.-) (CASP-8) (ICE-like apoptotic protease 5) (MORT1-associated CED-3 homolog) (MACH) (FADD-homologous ICE/CED-3-like protease) (FADD-like ICE) (FLICE) (Apoptotic cysteine
EMBLCAA66853.1 
UCSCGenomeBrowserQ14790 
ENSEMBLENSP00000307131 
ENSEMBLENSP00000344731 
ENSEMBLENSP00000344731TDI sequence
ENSEMBLENSP00000412523