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ModBase: Database of Comparative Protein Structure Models

Model Details Page

Sequence Information

Primary Database Link P07949.3
Original Database ID sp P07949
Organism Homo sapiens
Annotation ret_human recname: full=proto-oncogene
tyrosine-protein kinase receptor
ret; alt name: full=cadherin family
member 12; altname: full=proto-oncogene
c- ...
Sequence Length 1114

Dataset Information:

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Model Information

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Target Region554-1011
Protein Length1114
Template PDB Code1fmkA
Template Region91-522
Sequence Identity26%
E-Value 0
GA3411
MPQS0.54
z-DOPE0.66
TSVMod MethodNO3.5S
TSVMod RMSD
TSVMod NO350.530656
Datasethuman_2008
ModPipe Version2.0.2
Model Date2008-11-05

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Cross-references

Show obsolete/secondary identifiers
Mutation Data
LS-Mut Somatic mutation found in glioblastoma multiforme for CCDS7200.1 R330W
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB1fmkcrystal structure of human tyrosine-protein kinase c-src ; EC: 2.7.1.112 ; PFAM: PF00017 PF00018 PF00069 ; SCOP: 24511 40436 41690
DBALI1fmkA 
CATH2.30.30.40 Domain: 1fmkA01 SH3 Domains (86%)
CATH3.30.505.10 Domain: 1fmkA02 SHC Adaptor Protein (100%)
CATH3.30.200.20 Domain: 1fmkA03 Phosphorylase Kinase; domain 1 (100%)
CATH1.10.510.10 Domain: 1fmkA04 Transferase(Phosphotransferase) domain 1 (100%)
JenaImageLibrary1fmk 
Target Sequence
UniProtKBQ9H4A2RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProQ9H4A2 
PFAMQ9H4A2 
ProdomQ9H4A2 
UniProtKBA8K6Z2RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProA8K6Z2 
PFAMA8K6Z2 
ProdomA8K6Z2 
UniProtKBP07949RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProP07949 
PFAMP07949 
ProdomP07949 
UniProtKBA0A024R7T2SubName: Full=Ret proto-oncogene (Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), isoform CRA_d {ECO:0000313|EMBL:EAW86580.1};
InterProA0A024R7T2 
PFAMA0A024R7T2 
ProdomA0A024R7T2 
UniProtKBQ15250RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProQ15250 
PFAMQ15250 
ProdomQ15250 
UniProtKBQ9BTB0RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProQ9BTB0 
PFAMQ9BTB0 
ProdomQ9BTB0 
UniProtKBQ15250RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProQ15250 
PFAMQ15250 
ProdomQ15250 
UniProtKBQ9BTB0RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProQ9BTB0 
PFAMQ9BTB0 
ProdomQ9BTB0 
UniProtKBP07949RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProP07949 
PFAMP07949 
ProdomP07949 
UniProtKBQ9H4A2RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProQ9H4A2 
PFAMQ9H4A2 
ProdomQ9H4A2 
UniProtKBA8K6Z2RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret;EC=2.7.10.1;AltName: Full=Cadherin family member 12;AltName: Full=Proto-oncogene c-Ret;Contains:RecName: Full=Soluble RET kinase fragm
InterProA8K6Z2 
PFAMA8K6Z2 
ProdomA8K6Z2 
UniProtKBP07949.3RET_HUMAN RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret; AltName: Full=Cadherin family member 12; AltName: Full=Proto-oncogene c-Ret; Flags: Precursor
InterProP07949.3 
PFAMP07949.3 
ProdomP07949.3 
RefSeqNP_066124.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform a [Homo sapiens]
GenPept88522S05582 protein-tyrosine kinase (EC 2.7.1.112) ret precursor - human
GenPept10862705 ret proto-oncogene, isoform a precursor,; hydroxyaryl-protein kinase; RET51; oncogene RET; RET transforming sequence; c
GenPept119606986ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), isoform CRA_d
GenPept119606988ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), isoform CRA_d
GenPept145582021unnamed protein product
GenPept14745662 ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) [Homo sapiens
GenPept14745687 ret proto-oncogene, isoform b precursor [Homo sapiens]
GenPept223087909Sequence 5925 from patent US 6812339
GenPept223088959Sequence 6975 from patent US 6812339
GenPept333676899Sequence 74 from patent US 7939268
GenPept334875502Sequence 74 from patent US 7951546
GenPept547807RET_HUMAN RecName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret; AltName: Full=Cadherin family member 12; AltName: Full=Proto-oncogene c-Ret; Flags: Precursor
GenPept915814100Sequence 2 from patent US 9006256
GenPept10862703 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor [Homo sapiens]
GenBankEAW86582.1 ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), isoform CRA_d [Homo sapiens]
GenBankEAW86580.1 ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease), isoform CRA_d [Homo sapiens]
ENSEMBLENSP00000344798Proto-oncogene tyrosine-protein kinase receptor ret precursor (EC 2.7.1.112) (C-ret). [Homo sapiens]
UCSCGenomeBrowserP07949 
ENSEMBLENSP00000344798 
ENSEMBLENSP00000344798TDI sequence
ENSEMBLENSP00000347942