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Sequence Information

Primary Database Link Q9GZX1
Original Database ID Custom ID
Organism Homo sapiens, synthetic construct
Annotation recname: full=epidermal growth
factor receptor;ec=2.7.10.1;altname:
full=proto-o ncogene c-erbb-1;altname:
full=receptor tyrosine-protein
kinase erbb- ...
Sequence Length 1210

Dataset Information:

The newest dataset for this sequence was created on 2021-07-22. If you think that a better template has been added to the template database since, you can start a new calculation.

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Model Information

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Target Region26-638
Protein Length1210
Template PDB Code1yy9A
Template Region2-614
Sequence Identity100%
E-Value0
GA3411
MPQS1.63451
z-DOPE-0.45
TSVMod MethodMTALL
TSVMod RMSD12.939
TSVMod NO350.464
DatasetMW-update_D10987
ModPipe VersionSVN.r1703
Model Date2021-07-22

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Cross-references

Show obsolete/secondary identifiers
Mutation Data
LS-Mut Somatic mutation found in glioblastoma multiforme for CCDS5514.1 G598V
PharmGKB   PharmGKB data available for EGFR
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB1yy9structure of the extracellular domain of the epidermal growth factor receptor in complex with the fab fragment of cetuximab/erbitux/imc-c225
DBALI1yy9A 
CATH3.80.20.20 Domain: 1yy9A01 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1 (100%)
CATH2.10.220.10 Domain: 1yy9A02 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 (100%)
CATH3.80.20.20 Domain: 1yy9A03 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1 (100%)
CATH2.10.220.10 Domain: 1yy9A04 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 (100%)
JenaImageLibrary1yy9 
Target Sequence
UniProtKBQ9GZX1RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9GZX1 
PFAMQ9GZX1 
ProdomQ9GZX1 
UniProtKBQ9H2C9RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9H2C9 
PFAMQ9H2C9 
ProdomQ9H2C9 
UniProtKBQ9H3C9RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9H3C9 
PFAMQ9H3C9 
ProdomQ9H3C9 
UniProtKBQ9UMD7RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9UMD7 
PFAMQ9UMD7 
ProdomQ9UMD7 
UniProtKBQ9UMD8RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9UMD8 
PFAMQ9UMD8 
ProdomQ9UMD8 
UniProtKBQ9UMG5RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9UMG5 
PFAMQ9UMG5 
ProdomQ9UMG5 
UniProtKBP00533.2EGFR_HUMAN RecName: Full=Epidermal growth factor receptor; AltName: Full=Proto-oncogene c-ErbB-1; AltName: Full=Receptor tyrosine-protein kinase erbB-1; Flags: Precursor
InterProP00533.2 
PFAMP00533.2 
ProdomP00533.2 
UniProtKBP06268Epidermal growth factor receptor {ECO:0000305}EC=2.7.10.1AltName: Full=Proto-oncogene c-ErbB-1AltName: Full=Receptor tyrosine-protein kinase erbB-1Flags: Precursor
InterProP06268 
PFAMP06268 
ProdomP06268 
UniProtKBQ14225Epidermal growth factor receptor {ECO:0000305}EC=2.7.10.1AltName: Full=Proto-oncogene c-ErbB-1AltName: Full=Receptor tyrosine-protein kinase erbB-1Flags: Precursor
InterProQ14225 
PFAMQ14225 
ProdomQ14225 
UniProtKBP00533EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112)
InterProP00533 
PFAMP00533 
ProdomP00533 
UniProtKBQ92795Epidermal growth factor receptor {ECO:0000305}EC=2.7.10.1AltName: Full=Proto-oncogene c-ErbB-1AltName: Full=Receptor tyrosine-protein kinase erbB-1Flags: Precursor
InterProQ92795 
PFAMQ92795 
ProdomQ92795 
UniProtKBQ9BZS2Epidermal growth factor receptor {ECO:0000305}EC=2.7.10.1AltName: Full=Proto-oncogene c-ErbB-1AltName: Full=Receptor tyrosine-protein kinase erbB-1Flags: Precursor
InterProQ9BZS2 
PFAMQ9BZS2 
ProdomQ9BZS2 
UniProtKBQ9GZX1RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9GZX1 
PFAMQ9GZX1 
ProdomQ9GZX1 
UniProtKBO00732Epidermal growth factor receptor {ECO:0000305}EC=2.7.10.1AltName: Full=Proto-oncogene c-ErbB-1AltName: Full=Receptor tyrosine-protein kinase erbB-1Flags: Precursor
InterProO00732 
PFAMO00732 
ProdomO00732 
UniProtKBQ9H2C9RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9H2C9 
PFAMQ9H2C9 
ProdomQ9H2C9 
UniProtKBQ9H3C9RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9H3C9 
PFAMQ9H3C9 
ProdomQ9H3C9 
UniProtKBQ9UMD7RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9UMD7 
PFAMQ9UMD7 
ProdomQ9UMD7 
UniProtKBQ9UMD8RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9UMD8 
PFAMQ9UMD8 
ProdomQ9UMD8 
UniProtKBQ9UMG5RecName: Full=Epidermal growth factor receptor;EC=2.7.10.1;AltName: Full=Proto-oncogene c-ErbB-1;AltName: Full=Receptor tyrosine-protein kinase erbB-1;Flags: Precursor;
InterProQ9UMG5 
PFAMQ9UMG5 
ProdomQ9UMG5 
UniProtKBO00688Epidermal growth factor receptor precursor (EC 2.7.1.112) (ReceptorDE protein-tyrosine kinase ErbB-1)
InterProO00688 
PFAMO00688 
ProdomO00688 
RefSeqNP_005219.2 epidermal growth factor receptor isoform a precursor [Homo sapiens]
GenPept56611474Sequence 2 from patent US 6790614
GenPept568532417Sequence 15613 from patent US 8586006
GenPept568597535Sequence 328 from patent US 8598113
GenPept61354737epidermal growth factor receptor
GenPept61354745epidermal growth factor receptor
GenPept683492225unnamed protein product
GenPept756322223Sequence 102 from patent US 8680041
GenPept756726104Sequence 35 from patent US 8808997
GenPept757046971Sequence 4 from patent US 8900816
GenPept757047106Sequence 25 from patent US 8900820
GenPept757889181Sequence 1 from patent US 8535670
GenPept84364924unnamed protein product
GenPept915429676Sequence 60 from patent US 8975374
GenPept915605067Sequence 1 from patent US 8987266
GenPept915673819Sequence 412 from patent US 8992932
GenPept916141786Sequence 36 from patent US 9017684
GenPept291048865unnamed protein product
GenPept534486350Sequence 94 from patent US 8506948
GenPept520724835Sequence 512 from patent US 8465916
GenPept11494380AF288738_4 p170 epidermal growth factor receptor
GenPept303195738Sequence 43 from patent US 7718391
GenPept314880838Sequence 1080 from patent US 7842467
GenPept314880841Sequence 1083 from patent US 7842467
GenPept331467611Sequence 35 from patent US 7892760
GenPept333647982Sequence 285 from patent US 7932031
GenPept333678142Sequence 427 from patent US 7939634
GenPept336158441Sequence 1 from patent US 7960118
GenPept339437750Sequence 512 from patent US 7964349
GenPept303074139Sequence 11 from patent US 7700299
GenPept29725609 epidermal growth factor receptor isoform a precursor [Homo sapiens]
GenPept119571347epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), isoform CRA_a
GenPept145582009unnamed protein product
GenPept14741798 epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) [Homo sapiens]
GenPept155076303Sequence 16 from patent US 7202033
GenPept218598250unnamed protein product
GenPept281036281Sequence 438 from patent US 7608413
GenPept281036282Sequence 439 from patent US 7608413
GenPept2811086EGFR_HUMAN RecName: Full=Epidermal growth factor receptor; AltName: Full=Proto-oncogene c-ErbB-1; AltName: Full=Receptor tyrosine-protein kinase erbB-1; Flags: Precursor
GenPept162472735Sequence 512 from patent US 7294468
GenPept475808388unnamed protein product
GenPept402606142Sequence 1 from patent US 8232053
GenPept402606168Sequence 1 from patent US 8232062
GenPept402640658Sequence 328 from patent US 8247375
GenPept425817573unnamed protein product
GenPept425817616unnamed protein product
GenPept430257236Sequence 2 from patent US 8323987
GenPept430384834Sequence 1 from patent US 8329421
GenPept449651522Sequence 2 from patent US 8367069
GenPept46241840epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
GenPept390152374Sequence 512 from patent US 8105769
GenPept389928451Sequence 760 from patent US 8168602
GenPept389728548Sequence 9 from patent US 8158361
GenPept380287550Sequence 25 from patent US 8129125
GenPept375661054Sequence 25 from patent US 8088589
GenPept344967633Sequence 439 from patent US 7998689
GenPept344967632Sequence 438 from patent US 7998689
GenPept333647885Sequence 1 from patent US 7932026
GenBankEAW50962.1 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), isoform CRA_a [Homo sapiens]
GenBankAAX41052.1 epidermal growth factor receptor [synthetic construct]
GenBankAAS83109.1 epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Homo sapiens]
GenBankAAG35789.1AF288738_4 p170 epidermal growth factor receptor [Homo sapiens]
GenBankAAX41053.1 epidermal growth factor receptor [synthetic construct]
ENSEMBLENSP00000275493Epidermal growth factor receptor precursor (EC 2.7.1.112) (Receptor tyrosine-protein kinase ErbB-1). [Homo sapiens]
ENSEMBLENSP00000275493 
ENSEMBLENSP00000275493TDI sequence
ENSEMBLENSP00000275493 
UCSCGenomeBrowserP00533