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ModBase: Database of Comparative Protein Structure Models

Model Details Page

Sequence Information

Primary Database Link A0A024R499
Original Database ID EN ENSP00000304895.4
Organism Homo sapiens
Annotation subname: full=insulin receptor
substrate 1, isoform cra_a {eco:0000313|embl:eaw7
0838.1};
Sequence Length 1242

Dataset Information:

The newest dataset for this sequence was created on 2020-05-15. If you think that a better template has been added to the template database since, you can start a new calculation.

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Model Information

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Target Region12-262
Protein Length1242
Template PDB Code1qqgA
Template Region12-262
Sequence Identity100%
E-Value0
GA3411
MPQS1.11879
z-DOPE-0.37
TSVMod MethodMSALL
TSVMod RMSD2.419
TSVMod NO350.967
DatasetMW-Human_D15
ModPipe VersionSVN.r1693
Model Date2020-05-15

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Cross-references

Show obsolete/secondary identifiers
Mutation Data
LS-Mut Somatic mutation found in glioblastoma multiforme for CCDS2463.1 Y47C
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB1qqgcrystal structure of the ph-ptb targeting region of irs-1 ; PFAM: PF00169 PF02174 ; SCOP: 26987 26988
DBALI1qqgA 
CATH2.30.29.30 Domain: 1qqgA01 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) (100%)
CATH2.30.29.30 Domain: 1qqgA02 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) (100%)
JenaImageLibrary1qqg 
Target Sequence
UniProtKBP35568RecName: Full=Insulin receptor substrate 1;Short=IRS-1;
InterProP35568 
PFAMP35568 
ProdomP35568 
UniProtKBA0A024R499SubName: Full=Insulin receptor substrate 1, isoform CRA_a {ECO:0000313|EMBL:EAW70838.1};
InterProA0A024R499 
PFAMA0A024R499 
ProdomA0A024R499 
UniProtKBP35568RecName: Full=Insulin receptor substrate 1;Short=IRS-1;
InterProP35568 
PFAMP35568 
ProdomP35568 
UniProtKBP35568.1IRS1_HUMAN RecName: Full=Insulin receptor substrate 1; Short=IRS-1
InterProP35568.1 
PFAMP35568.1 
ProdomP35568.1 
RefSeqNP_005535.1 insulin receptor substrate 1 [Homo sapiens]
GenPept56580025Sequence 5 from patent US 6783758
GenPept547738IRS1_HUMAN RecName: Full=Insulin receptor substrate 1; Short=IRS-1
GenPept5031805 insulin receptor substrate 1 [Homo sapiens]
GenPept407102872Sequence 46 from patent US 8263357
GenPept389926913Sequence 329 from patent US 8168588
GenPept386257insulin receptor substrate-1
GenPept56626945Sequence 5 from patent US 6797696
GenPept56643919Sequence 5 from patent US 6812206
GenPept56645146Sequence 5 from patent US 6815415
GenPept59753249Sequence 5 from patent US 6835370
GenPept649101007IRS1, partial
GenPept756757600Sequence 46 from patent US 8815530
GenPept756818900Sequence 29 from patent US 8828959
GenPept190689515insulin receptor substrate 1 protein, partial
GenPept363882277Sequence 339 from patent US 8071302
GenPept363882276Sequence 338 from patent US 8071302
GenPept333689330Sequence 46 from patent US 7943732
GenPept29161817unnamed protein product
GenPept217112386Sequence 29 from patent US 7417033
GenPept2135481JS0670 insulin receptor substrate-1 - human
GenPept168270828insulin receptor substrate 1, partial
GenPept14730386 insulin receptor substrate 1 [Homo sapiens]
GenPept119591245insulin receptor substrate 1, isoform CRA_a
GenPept119591244insulin receptor substrate 1, isoform CRA_a
GenPept115799496Sequence 5 from patent US 7094556
GenPept295040849unnamed protein product
GenPept29698622Sequence 1 from patent US 6498139
GenPept303219053Sequence 1 from patent US 7731964
GenPept303220152Sequence 1 from patent US 7732151
GenPept314647346Sequence 338 from patent US 7820380
GenPept314647347Sequence 339 from patent US 7820380
GenPept31753081Insulin receptor substrate 1
GenPept314882351Sequence 2593 from patent US 7842467
GenPept314882350Sequence 2592 from patent US 7842467
GenPept314882349Sequence 2591 from patent US 7842467
GenBankEAW70838.1 insulin receptor substrate 1, isoform CRA_a [Homo sapiens]
GenBankACE86532.1 insulin receptor substrate 1 protein [synthetic construct]
GenBankAAH53895.1 Insulin receptor substrate 1 [Homo sapiens]
GenBankAAB27175.1 insulin receptor substrate-1 [Homo sapiens]
GenBankEAW70839.1 insulin receptor substrate 1, isoform CRA_a [Homo sapiens]
ENSEMBLENSP00000304895Insulin receptor substrate-1 (IRS-1). [Homo sapiens]
UCSCGenomeBrowserP35568 
ENSEMBLENSP00000304895 
ENSEMBLENSP00000304895TDI sequence
ENSEMBLENSP00000304895