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Search Input:database_id: P42575
 
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TARGETMODEL DATATEMPLATE
Model
Icon 		Model/Fold
Reliability 		Sequence
Database
Link 		Database AnnotationOrganismProtein
Size		Modeled
Segment		SizeSeq
Id(%)		PDB
code		PDB
Segment		PDB Comment
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens45232-12089333ygsP2-92apaf-1 card in complex
with prodomain of procaspase-9
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens435175-428254311f1jA60-301crystal structure of
caspase-7 in complex
with acetyl-asp-glu-val-asp-cho
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens45240-12081353ygsP10-92apaf-1 card in complex
with prodomain of procaspase-9
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens452188-447260301i4eB2222-2478crystal structure of
the caspase-8/p35 complex
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens435162-428267291m72A40-293crystal structure of
caspase-1 from spodoptera
frugiperda
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens43515-10389333ygsP2-92apaf-1 card in complex
with prodomain of procaspase-9
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45232-11887181z6tA1-87structure of the apoptotic
protease-activating
factor 1 bound to adp
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens43515-9177323crd1-78nmr structure of the
raidd card domain, 15
structures
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens435165-428264331nw9B143-413structure of caspase-9
in an inhibitory complex
with xiap-bir3
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452165-449285232fp3A162-447crystal structure of
the drosophila initiator
caspase dronc
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens45232-10877323crd1-78nmr structure of the
raidd card domain, 15
structures
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452174-3321591001pyoA9-167crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452174-3321591001pyoA9-167crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452174-3321591001pyoA9-167crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452174-3321591001pyoA9-167crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens43515-10894283crd1-97nmr structure of the
raidd card domain, 15
structures
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45232-11887214p4hA1-89
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452163-449287232fp3A160-447crystal structure of
the drosophila initiator
caspase dronc
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452176-449274313e4cA133-404procaspase-1 zymogen
domain crystal strucutre
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens452354-451981001pyoB207-304crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45237-11882221dgnA3-87solution structure of
iceberg, an inhibitor
of interleukin-1beta
generation
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452354-451981001pyoB207-304crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45232-11887181cy5A1-87crystal structure of
the apaf-1 card
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45236-11782164i16A22-106
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45232-11887283ygsP2-90apaf-1 card in complex
with prodomain of procaspase-9
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens45237-11983231dgnA3-89solution structure of
iceberg, an inhibitor
of interleukin-1beta
generation
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452166-447282324m9rA209-496
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45232-11887284rhwE1-89
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens43515-172158141z6tA1-158structure of the apoptotic
protease-activating
factor 1 bound to adp
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens452192-445254311f1jA60-301crystal structure of
caspase-7 in complex
with acetyl-asp-glu-val-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452160-448289232fp3A157-446crystal structure of
the drosophila initiator
caspase dronc
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens452182-445264331nw9B143-413structure of caspase-9
in an inhibitory complex
with xiap-bir3
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45232-11180303crdA1-81nmr structure of the
raidd card domain, 15
structures
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens435172-430259301i4eB2223-2478crystal structure of
the caspase-8/p35 complex
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens435163-431269291gqfA144-402crystal structure of
human procaspase-7
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens43515-10591181cy5A1-91crystal structure of
the apaf-1 card
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452174-3321591001pyoA9-167crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
37589083caspase 2, apoptosis-related
cysteine peptidase		Homo sapiens452191-446256314ehkA36-276
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452354-451981001pyoB207-304crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452174-3321591001pyoA9-167crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens43515-11096273crd1-96nmr structure of the
raidd card domain, 15
structures
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452198-412215123bijA2-249crystal structure of
protein gsu0716 from
geobacter sulfurreducens.
northeast structural
genomics target gsr13
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens435172-429258311nmsA34-276caspase-3 tethered to
irreversible inhibitor
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452357-44690272dkoB186-276extended substrate recognition
in caspase-3 revealed
by high resolution x-ray
structure analysis
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452166-447282324m9rA209-496
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		452174-3321591001pyoA9-167crystal structure of
human caspase-2 in complex
with acetyl-leu-asp-glu-ser-asp-cho
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45236-11580244uz0A8-92
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45231-12494283ygsP1-96apaf-1 card in complex
with prodomain of procaspase-9
P42575.2casp2_human recname: full=caspase-2;
short=casp-2; altname: full=neural
precurso r cell expressed
developmentally down-regulated
protein 2; short=nedd-2;
altname: full=protease ich-1;
contains: recname		Pan paniscus, Pan
troglodytes, etc.		45232-12392284rhwE1-94
P42575caspase-2 precursor (ec 3.4.22.-)
(casp-2) (ich-1 protease)
(ich-de 1l/1s) [co ntains:
caspase-2 subunit p18; caspase-2
subunit p13;de caspase-2
subunit p12]		Homo sapiens435174-429256321nmsA36-276caspase-3 tethered to
irreversible inhibitor