Cluster Family - ABC Transporter

ATP-binding cassette (ABC) transporters are membrane-spanning proteins that transport a wide variety of small molecule substrates and ions across cell membranes. Examples include the multidrug transporter P-gp, associated with drug resistance phenotypes in cancer therapy, and the cystic fibrosis transmembrane conductance regulator (CFTR) that transports chloride ions. In Escherischia coli, the vitamin B12 transporter BtuCD is also an ABC transporter, further underscoring the diversity of molecules transported by these proteins.

While the fold of ABC transporters are predicted to be very similar to each other, the diverge significantly in sequence space. This is reflected in the relatively large number of human domain clusters with ABC transporters.

ABC transporter from https://modbase.compbio.ucsf.edu/modbase/projects/ABC/ have been mapped onto 33 sequences in the human transmembrane domain sequences, which fall into 12 clusters. Only three clusters contain more than 3 sequences each.

GI ID Cluster ID Cluster Size Annotation
157502201 118582255 9 SubName: Full=ATP-binding cassette transporter C4 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4, isoform CRA_c) (ATP-binding cassette, sub-family C (CFTR/MRP), member 4);
21729873 118582255 9 Q8TDJ0_chr16:47979148-48043792_E317 ATP-binding cassette protein C11 isoform A
89111135 118582255 9 ABCC12 protein
66529005 118582255 9 RecName: Full=Multidrug resistance-associated protein 5;AltName: Full=ATP-binding cassette sub-family C member 5;AltName: Full=Multi-specific organic anion transporter C;Short=MOAT-C;AltName: Full=SMR
190343023 118582255 9 multidrug resistance-associated protein 6 isoform 1 [Homo sapiens]
110832835 118582255 9 RecName: Full=ATP-binding cassette transporter sub-family C member 9;AltName: Full=Sulfonylurea receptor 2;
4557481 118582255 9 RecName: Full=Canalicular multispecific organic anion transporter 1;AltName: Full=ATP-binding cassette sub-family C member 2;AltName: Full=Canalicular multidrug resistance protein;AltName: Full=Multid
134142335 118582255 9 SubName: Full=Putative uncharacterized protein ABCC1;
118582255 118582255 9 RecName: Full=ATP-binding cassette sub-family C member 8;AltName: Full=Sulfonylurea receptor 1;
11967971 11967969 5 RecName: Full=ATP-binding cassette sub-family G member 8;AltName: Full=Sterolin-2;
215820660 11967969 5 Putative white family ATP-binding cassette transporter
46592915 11967969 5 RecName: Full=ATP-binding cassette sub-family G member 1;AltName: Full=ATP-binding cassette transporter 8;AltName: Full=White protein homolog;
62526033 11967969 5 ABC transporter ABCG2
11967969 11967969 5 RecName: Full=ATP-binding cassette sub-family G member 5;AltName: Full=Sterolin-1;
6005701 27262624 5 O94911_chr17:67461352-67548507_F499 KIAA0822 PROTEIN
153792144 27262624 5 SubName: Full=Putative uncharacterized protein ABCA10;
27436953 27262624 5 Hypothetical protein
27477115 27262624 5 RecName: Full=ATP-binding cassette sub-family A member 9;
27262624 27262624 5 RecName: Full=ATP-binding cassette sub-family A member 5;
150417984 105990541 3 ABC transporter ABCA7
21536376 105990541 3 SubName: Full=ATP-binding cassette, sub-family A (ABC1), member 1;
105990541 105990541 3 RecName: Full=Retinal-specific ATP-binding cassette transporter;AltName: Full=ATP-binding cassette sub-family A member 4;AltName: Full=RIM ABC transporter;Short=RIM protein;Short=RmP;AltName: Full=Sta
9961252 21536378 3 SubName: Full=ATP-binding cassette, sub-family B (MDR/TAP), member 4;SubName: Full=ATP-binding cassette, sub-family B (MDR/TAP), member 4, isoform CRA_f;
42741659 21536378 3 SubName: Full=ATP-binding cassette, sub-family B (MDR/TAP), member 1;SubName: Full=ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_c;SubName: Full=Multidrug resistance protein 1;
21536378 21536378 3 RecName: Full=Bile salt export pump;AltName: Full=ATP-binding cassette sub-family B member 11;
116734710 116734710 1 Lamellar body membrane specific ATP-binding cassette protein (ATP-DE binding cassette, sub-family A (ABC1), member 3)
156105685 156105685 1 ATP-binding cassette, sub-family B, member 8 variant (ATP-bindingcassette, sub-family B (MDR/TAP), member 8, isoform CRA_g) (ATP-binding cassette, sub-family B (MDR/TAP), member 8) (Fragment).
221316556 221316556 1 canalicular multispecific organic anion transporter 2 isoform 2 [Homo sapiens]
27881501 27881501 1 ATP-binding cassette sub-family A member 12 isoform b [Homo sapiens]
90421313 90421313 1 P13569_chr7:116674652-116861662_L693 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) (CAMP-DE DEPENDENT CHLORIDE CHANNEL)
9955963 9955963 1 RecName: Full=ATP-binding cassette sub-family B member 6, mitochondrial;AltName: Full=Mitochondrial ABC transporter 3;Short=Mt-ABC transporter 3;AltName: Full=P-glycoprotein-related protein;AltName: F