Cluster Family - Claudins

Claudins are a family of proteins that are the most important components of the tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm.

23 human Claudins have been previously identified (Louis Metzger, private communication). All of these sequences form one of the clusters, which has one additional putative claudin (GI Id 297206813) with only three transmembrane helices. Additionally, one shorter isoform of claudin 11, also with only three transmembrane helices, forms its own cluster at the 70% coverage cutoff. At 50%, the sequence gets included in the main claudin cluster.

GI ID Cluster GI ID Cluster Size Annotation
195947374 5729970 24 SubName: Full=Claudin 5 (Transmembrane protein deleted in velocardiofacial syndrome), isoform CRA_a;
225703142 5729970 24 RecName: Full=Claudin-14;
283806634 5729970 24 RecName: Full=Claudin-2;AltName: Full=SP82;
297206811 5729970 24 SubName: Full=Claudin 7, isoform CRA_a;
6912316 5729970 24 RecName: Full=Claudin-17;
40788011 5729970 24 RecName: Full=Claudin-8;
7705961 5729970 24 RecName: Full=Claudin-18;
50345279 5729970 24 AF349452_1 claudin-18A2.1 [Homo sapiens]
5729970 5729970 24 RecName: Full=Claudin-16;AltName: Full=Paracellin-1;Short=PCLN-1;
297206813 5729970 24 NULL
231569235 5729970 24 claudin-10 isoform a_i1 [Homo sapiens]
4502877 5729970 24 RecName: Full=Claudin-4;AltName: Full=Clostridium perfringens enterotoxin receptor;Short=CPE-R;Short=CPE-receptor;AltName: Full=Williams-Beuren syndrome chromosomal region 8 protein;
297632383 5729970 24 NULL
153792768 5729970 24 RecName: Full=Claudin-6;AltName: Full=Skullin;
124107616 5729970 24 RecName: Full=Claudin-23;
11141861 5729970 24 RecName: Full=Claudin-9;
297515455 5729970 24 RecName: Full=Claudin-15;
5921465 5729970 24 RecName: Full=Claudin-10;AltName: Full=OSP-like protein;
162417973 5729970 24 Hypothetical protein FLJ40745
10863887 5729970 24 RecName: Full=Claudin-1;AltName: Full=Senescence-associated epithelial membrane protein;
157820127 5729970 24 SubName: Full=HCG1646420;SubName: Full=Putative uncharacterized protein CLDN25;
47716519 5729970 24 RecName: Full=Claudin-20;
183979975 5729970 24 SubName: Full=Claudin-19;SubName: Full=Claudin 19, isoform CRA_b;
4502875 5729970 24 RecName: Full=Claudin-3;AltName: Full=Clostridium perfringens enterotoxin receptor 2;Short=CPE-R 2;Short=CPE-receptor 2;AltName: Full=Rat ventral prostate.1 protein homolog;Short=hRVP1;
297374750 297374750 1 claudin 11 (oligodendrocyte transmembrane protein), isoform CRA_b [Homo sapiens]