Cluster Family - Solute Carriers

Solute carriers are eukaryotic membrane proteins that control the uptake and efflux of solutes, including essential cellular compounds, environmental toxins, and therapeutic drugs. Solute carriers can share similar structural features despite weak sequence similarities. Identification of sequence relationships among solute carriers is needed to enhance our ability to model individual carriers and to elucidate the molecular mechanisms of their substrate specificity and transport.

We recently proposed a new classification of human solute carriers (Avner's paper). Here, we compare this classification with SLC sequences in the human transmembrane domain clusters.

340 of XXX SLC sequences are included 116 domain clusters. 17 of these clusters have four or more cluster members. The majority of sequences in the clusters have been previously annotated as solute carriers. XX sequences are annotated as "uncharacterized","fragment", etc.
Remark: look at the annotations with Avner.

Examples of one member of each of the first 17 clusters are shown in the table:

GI ID Cluster ID Cluster Size Annotation
5730045 34916028 14 SubName: Full=Solute carrier family 16 (Monocarboxylic acid transporters), member 2, isoform CRA_a;SubName: Full=Solute carrier family 16, member 2 (Monocarboxylic acid transporter 8);
225543525 225543525 12 RecName: Full=Solute carrier organic anion transporter family member 1B1;AltName: Full=Liver-specific organic anion transporter 1;Short=LST-1;AltName: Full=OATP-C;AltName: Full=Sodium-independent orga
7657683 4507047 12 RecName: Full=Cystine/glutamate transporter;AltName: Full=Amino acid transport system xc-;AltName: Full=Calcium channel blocker resistance protein CCBR1;AltName: Full=Solute carrier family 7 member 11
256985183 110835708 11 SubName: Full=Solute carrier family 5 (Sodium-dependent vitamin transporter), member 6;SubName: Full=Putative uncharacterized protein SLC5A6;
65506789 100913030 10 Solute carrier family 26 member 10 (Fragment).
4507021 125987596 10 RecName: Full=Band 3 anion transport protein;AltName: Full=Anion exchange protein 1;Short=AE 1;Short=Anion exchanger 1;AltName: Full=Solute carrier family 4 member 1;AltName: CD_antigen=CD233;
21361449 4557851 10 Glucose transporter 8
154350196 148743791 9 RecName: Full=Solute carrier family 17 member 9;
27735137 21361602 9 CDNA FLJ39822 fis, clone SPLEN2011830 (Putative uncharacterizedprotein FLJ39822).
27777632 27777632 9 RecName: Full=Sodium/hydrogen exchanger 1;AltName: Full=APNH;AltName: Full=Na(+)/H(+) antiporter, amiloride-sensitive;AltName: Full=Na(+)/H(+) exchanger 1;Short=NHE-1;AltName: Full=Solute carrier fami
301069346 225637549 6 SubName: Full=cDNA FLJ59540, highly similar to Solute carrier family 13 member 3;
24308414 4506973 6 Hypothetical protein
262359914 4827012 6 SubName: Full=Glutamate transporter variant EAAT1ex9skip;
21361112 222080086 5 SubName: Full=Solute carrier family 30 (Zinc transporter), member 3 (cDNA, FLJ94169, Homo sapiens solute carrier family 30 (zinc transporter), member 3 (SLC30A3), mRNA) (Putative uncharacterized prote
56549677 51702206 5 SubName: Full=Uncharacterized protein SLC41A3;