Solute carriers are eukaryotic membrane proteins that control the uptake and efflux of solutes, including essential cellular compounds, environmental toxins, and therapeutic drugs. Solute carriers can share similar structural features despite weak sequence similarities. Identification of sequence relationships among solute carriers is needed to enhance our ability to model individual carriers and to elucidate the molecular mechanisms of their substrate specificity and transport.
We recently proposed a new classification of human solute carriers (Avner's paper). Here, we compare this classification with SLC sequences in the human transmembrane domain clusters.
340 of XXX SLC sequences are included 116 domain clusters. 17 of these clusters have four or more cluster members. The majority of sequences in the clusters have been previously annotated as solute carriers. XX sequences are annotated as "uncharacterized","fragment", etc.
Remark: look at the annotations with Avner.
Examples of one member of each of the first 17 clusters are shown in the table:
|GI ID||Cluster ID||Cluster Size||Annotation|
|5730045||34916028||14||SubName: Full=Solute carrier family 16 (Monocarboxylic acid transporters), member 2, isoform CRA_a;SubName: Full=Solute carrier family 16, member 2 (Monocarboxylic acid transporter 8);|
|225543525||225543525||12||RecName: Full=Solute carrier organic anion transporter family member 1B1;AltName: Full=Liver-specific organic anion transporter 1;Short=LST-1;AltName: Full=OATP-C;AltName: Full=Sodium-independent orga|
|7657683||4507047||12||RecName: Full=Cystine/glutamate transporter;AltName: Full=Amino acid transport system xc-;AltName: Full=Calcium channel blocker resistance protein CCBR1;AltName: Full=Solute carrier family 7 member 11|
|256985183||110835708||11||SubName: Full=Solute carrier family 5 (Sodium-dependent vitamin transporter), member 6;SubName: Full=Putative uncharacterized protein SLC5A6;|
|65506789||100913030||10||Solute carrier family 26 member 10 (Fragment).|
|4507021||125987596||10||RecName: Full=Band 3 anion transport protein;AltName: Full=Anion exchange protein 1;Short=AE 1;Short=Anion exchanger 1;AltName: Full=Solute carrier family 4 member 1;AltName: CD_antigen=CD233;|
|21361449||4557851||10||Glucose transporter 8|
|154350196||148743791||9||RecName: Full=Solute carrier family 17 member 9;|
|27735137||21361602||9||CDNA FLJ39822 fis, clone SPLEN2011830 (Putative uncharacterizedprotein FLJ39822).|
|27777632||27777632||9||RecName: Full=Sodium/hydrogen exchanger 1;AltName: Full=APNH;AltName: Full=Na(+)/H(+) antiporter, amiloride-sensitive;AltName: Full=Na(+)/H(+) exchanger 1;Short=NHE-1;AltName: Full=Solute carrier fami|
|301069346||225637549||6||SubName: Full=cDNA FLJ59540, highly similar to Solute carrier family 13 member 3;|
|262359914||4827012||6||SubName: Full=Glutamate transporter variant EAAT1ex9skip;|
|21361112||222080086||5||SubName: Full=Solute carrier family 30 (Zinc transporter), member 3 (cDNA, FLJ94169, Homo sapiens solute carrier family 30 (zinc transporter), member 3 (SLC30A3), mRNA) (Putative uncharacterized prote|
|56549677||51702206||5||SubName: Full=Uncharacterized protein SLC41A3;|