Current Target Lists

Current SG Target Lists

For the target selection strategy that we are considering, all human transmembrane domains are clustered into similar groups, so that most of the targets in the group, if structurally characterized, would be sufficiently close to all other targets in the group, that a reliable model for them can get created. For this reason, the current targets of the membrane structural genomics centers have been compared to the human transmembrane domains at high sequence identity (90%). At this level, it would be reasonable to assume, that the structure determination of any of these targets would also allow us to model any of the targets in the cluster group.

The current target lists of the membrane SG centers were also compared to the human transmembrane domains at lower sequence identity. As expected, the number of human TM domains that are related to current targets is significantly higher at this level.

Please use the link in the pull-down menu (Current Target Lists -> SG Center Matches), for specific results. All membrane SG center targets are listed on the "SG Center Targets" pages.

Center Number of Total Targets Number of Targets that match human TMH domains

(Sequence identity/Coverage in %)
25/50 25/90 30/50 30/90 90/50 90/90
CSMP 1,919 843 360 507 254 108 100
GPCR 109 109 109 109 109 109 108
MPID 50 8 1 2 0 0 0
MPSBC 10 6 3 4 1 0 0
MPSbyNMR 10 7 6 6 4 5 4
NYCOMPS 12,510 4,985 1,502 2,871 929 100 98
TEMIMPS 44 16 11 14 11 8 8
TMPC 66 33 27 30 22 9 9
TransportPDB 43 42 42 42 40 38 36
Total (unique sequences) 13,489 6,049 2,061 3,585 1,370 377 363

* The numbers come directly from the TargetTrack web-interface, which doesn't differentiate between PSI-2 and PSI-3

Center Number of human transmembrane domains that match PSI:Biology targets
(Sequence identity/Coverage in %)
25/50 25/90 30/50 30/90 90/50 90/90
CSMP 1,576 888 1,012 608 102 94
GPCR 834 733 746 683 155 152
MPID 12 1 2 0 0 0
MPSBC 32 4 8 1 0 0
MPSbyNMR 27 14 15 8 6 5
NYCOMPS 2,138 1,078 1,287 697 60 58
TEMIMPS 183 126 88 72 8 8
TMPC 343 276 178 137 10 10
TransportPDB 205 155 170 138 58 54
Total (unique sequences) 3,281 2,169 2,462 1,703 398 371