Random Tid-Bits

Sequences with large number of homologs

Most sequences have non-human homolog counts in the hundreds. However, a few classes of sequences have a significantly higher number of homologs. Here is a list of the top-homolog sequences:

  • The winner: Cytochrome B (70,000)
  • Runners up: GPCR sequences: 430 GPCR sequences have 1,000 to 40,000 non-human homologs
  • Still in the running: Cytochrome C (20,000)
  • Some ATPases also have a large number of homologs
  • Solute carrier proteins have up to 2,000 homologs each
  • 6 ABC transporters have 1,000 to 7,000 homologs


Highest number of TM helices

The sequence with the largest number of predicted transmembrane helices is http://uniprot.org/uniprot/B7Z812 : Piezo-type mechanosensitive ion channel component 2.
Alternative name: Protein FAM38B
Sequence length: 2752 AA
Details on this site: 257900451