Supplementary Figures

Supplementary Figure 1. a) The number of sequences with a given number of predicted transmembrane α-helices in human transmembrane domains. The number of
sequences with one predicted transmembrane α−helix is indicated by a hashed bar; these sequences have not been included in the subsequent analysis. b) Modeling the human α-helical transmembrane domain proteome based on currently known structures. The number of modeled domains is shown as a function of the modeling coverage threshold (percent sequence residues covered), for the sequence identity thresholds ranging from 20% to 100%. The number of domains that can be modeled increases with the lower sequence identity and lower model coverage thresholds.