MultiFit is a computational method for simultaneously fitting atomic structures
of components into their assembly density map at resolutions as low as 25 Å.
The component positions and orientations are optimized with respect to a scoring
function that includes the quality-of-fit of components in the map, the protrusion
of components from the map envelope, as well as the shape complementarity between
pairs of components.
The scoring function is optimized by an exact inference optimizer DOMINO that
efficiently finds the global minimum in a discrete sampling space.