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Model Details Page

Sequence Information

Primary Database Link B2R7N7
Original Database ID MKK4
Organism Cercocebus atys, Cercocebus torquatus atys, etc.
Annotation recname: full=dual specificity
mitogen-activated protein kinase
kinase 4;short=m ap kinase kinase
4;short=mapkk 4;ec=2.7.12.2;altname:
full=jnk-activa ...
Sequence Length 399

Dataset Information:

The newest dataset for this sequence was created on 2020-05-15. If you think that a better template has been added to the template database since, you can start a new calculation.

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Model Information

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Target Region83-389
Protein Length399
Template PDB Code3alnA
Template Region83-389
Sequence Identity100%
E-Value0
GA3411
MPQS1.77252
z-DOPE-0.61
TSVMod MethodMSALL
TSVMod RMSD2.424
TSVMod NO350.985
DatasetMW-Human_D15
ModPipe VersionSVN.r1693
Model Date2020-05-15

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Cross-references

Show obsolete/secondary identifiers
Mutation Data
LS-SNP SNP Information available through LS-SNP
Template Structure
PDB3aln
DBALI3alnA 
JenaImageLibrary3aln 
Target Sequence
UniProtKBQ6PIE6RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ6PIE6 
PFAMQ6PIE6 
ProdomQ6PIE6 
UniProtKBH2NSS3SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000008986};
InterProH2NSS3 
PFAMH2NSS3 
ProdomH2NSS3 
UniProtKBP45985RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProP45985 
PFAMP45985 
ProdomP45985 
UniProtKBK7APE5SubName: Full=Mitogen-activated protein kinase kinase 4 {ECO:0000313|EMBL:JAA01625.1};
InterProK7APE5 
PFAMK7APE5 
ProdomK7APE5 
UniProtKBQ5U0B8RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ5U0B8 
PFAMQ5U0B8 
ProdomQ5U0B8 
UniProtKBQ6FHX4RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ6FHX4 
PFAMQ6FHX4 
ProdomQ6FHX4 
UniProtKBQ6P9H2RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ6P9H2 
PFAMQ6P9H2 
ProdomQ6P9H2 
UniProtKBG1RWT9SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSNLEP00000017716};
InterProG1RWT9 
PFAMG1RWT9 
ProdomG1RWT9 
UniProtKBF7FU91SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSMMUP00000026088};
InterProF7FU91 
PFAMF7FU91 
ProdomF7FU91 
UniProtKBB2R7N7RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProB2R7N7 
PFAMB2R7N7 
ProdomB2R7N7 
UniProtKBD3DTS5RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProD3DTS5 
PFAMD3DTS5 
ProdomD3DTS5 
UniProtKBB3KYB2RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProB3KYB2 
PFAMB3KYB2 
ProdomB3KYB2 
UniProtKBF7FU91SubName: Full=Uncharacterized protein;
InterProF7FU91 
PFAMF7FU91 
ProdomF7FU91 
UniProtKBA0A2K6PJ85Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011}
InterProA0A2K6PJ85 
PFAMA0A2K6PJ85 
ProdomA0A2K6PJ85 
UniProtKBA0A2K5WTM3Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011}
InterProA0A2K5WTM3 
PFAMA0A2K5WTM3 
ProdomA0A2K5WTM3 
UniProtKBA0A2K5NJ62Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011}
InterProA0A2K5NJ62 
PFAMA0A2K5NJ62 
ProdomA0A2K5NJ62 
UniProtKBH2NSS3SubName: Full=Uncharacterized protein;
InterProH2NSS3 
PFAMH2NSS3 
ProdomH2NSS3 
UniProtKBA0A2J8MGY6SubName: Full=Mitogen-activated protein kinase kinase 4 {ECO:0000313|EMBL:JAA01625.1, ECO:0000313|Ensembl:ENSPTRP00000081869}
InterProA0A2J8MGY6 
PFAMA0A2J8MGY6 
ProdomA0A2J8MGY6 
UniProtKBA0A663DAF5SubName: Full=MAP2K4 isoform 2 {ECO:0000313|EMBL:PNJ31658.1}
InterProA0A663DAF5 
PFAMA0A663DAF5 
ProdomA0A663DAF5 
UniProtKBA0A2J8TFE2SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSPPYP00000008986}
InterProA0A2J8TFE2 
PFAMA0A2J8TFE2 
ProdomA0A2J8TFE2 
UniProtKBA0A6D2XM93SubName: Full=MAP2K4 isoform 1 {ECO:0000313|EMBL:PNI58774.1}
InterProA0A6D2XM93 
PFAMA0A6D2XM93 
ProdomA0A6D2XM93 
UniProtKBA0A8C9IQQ8SubName: Full=Mitogen-activated protein kinase kinase 4 {ECO:0000313|Ensembl:ENSPTEP00000040159}
InterProA0A8C9IQQ8 
PFAMA0A8C9IQQ8 
ProdomA0A8C9IQQ8 
UniProtKBQ5U0B8Mitogen-activated protein kinase kinase 4
InterProQ5U0B8 
PFAMQ5U0B8 
ProdomQ5U0B8 
UniProtKBA0A8D2GJB5SubName: Full=Mitogen-activated protein kinase kinase 4 {ECO:0000313|Ensembl:ENSTGEP00000034994}
InterProA0A8D2GJB5 
PFAMA0A8D2GJB5 
ProdomA0A8D2GJB5 
UniProtKBD3DTS5SubName: Full=Mitogen-activated protein kinase kinase 4, isoform CRA_b;
InterProD3DTS5 
PFAMD3DTS5 
ProdomD3DTS5 
UniProtKBG1RWT9SubName: Full=Uncharacterized protein;
InterProG1RWT9 
PFAMG1RWT9 
ProdomG1RWT9 
UniProtKBB3KYB2RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProB3KYB2 
PFAMB3KYB2 
ProdomB3KYB2 
UniProtKBB2R7N7RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProB2R7N7 
PFAMB2R7N7 
ProdomB2R7N7 
UniProtKBD3DTS5RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProD3DTS5 
PFAMD3DTS5 
ProdomD3DTS5 
UniProtKBQ6PIE6RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ6PIE6 
PFAMQ6PIE6 
ProdomQ6PIE6 
UniProtKBQ6P9H2RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ6P9H2 
PFAMQ6P9H2 
ProdomQ6P9H2 
UniProtKBQ6FHX4RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ6FHX4 
PFAMQ6FHX4 
ProdomQ6FHX4 
UniProtKBQ5U0B8RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProQ5U0B8 
PFAMQ5U0B8 
ProdomQ5U0B8 
UniProtKBP45985.1MP2K4_HUMAN RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4; Short=MAP kinase kinase 4; Short=MAPKK 4; AltName: Full=JNK-activating kinase 1; AltName: Full=MAPK/ERK kinase 4;
InterProP45985.1 
PFAMP45985.1 
ProdomP45985.1 
UniProtKBP45985RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4;Short=MAP kinase kinase 4;Short=MAPKK 4;EC=2.7.12.2;AltName: Full=JNK-activating kinase 1;AltName: Full=MAPK/ERK kinase 4;Short
InterProP45985 
PFAMP45985 
ProdomP45985 
RefSeqXP_031995653.1dual specificity mitogen-activated protein kinase kinase 4 isoform X1
RefSeqXP_025218074.1dual specificity mitogen-activated protein kinase kinase 4 isoform X2
RefSeqXP_023043860.1dual specificity mitogen-activated protein kinase kinase 4 isoform X1
RefSeqXP_008008602.1dual specificity mitogen-activated protein kinase kinase 4 isoform X2
RefSeqXP_011725660.1dual specificity mitogen-activated protein kinase kinase 4 isoform X2
RefSeqXP_003912410.1dual specificity mitogen-activated protein kinase kinase 4 isoform X2
RefSeqXP_002827100.2dual specificity mitogen-activated protein kinase kinase 4
RefSeqXP_001114330.1 PREDICTED: dual specificity mitogen-activated protein kinase kinase 4 isoform 2 [Macaca mulatta]
RefSeqXP_034798255.1dual specificity mitogen-activated protein kinase kinase 4 isoform X2
RefSeqNP_003001.1 dual specificity mitogen-activated protein kinase kinase 4 [Homo sapiens]
RefSeqXP_033040407.1dual specificity mitogen-activated protein kinase kinase 4 isoform X2
GenPept10062182Sequence 92 from patent US 5989885
GenPept54696220mitogen-activated protein kinase kinase 4
GenPept53972117Sequence 1129 from patent US 6753314
GenPept4506889 dual specificity mitogen-activated protein kinase kinase 4 [Homo sapiens]
GenPept407102891Sequence 65 from patent US 8263357
GenPept40091397Sequence 10 from patent US 6610523
GenPept3991115AR000965 Sequence 10 from patent US 5736381
GenPept333689349Sequence 65 from patent US 7943732
GenPept31691338Sequence 10 from patent US 6541605
GenPept307686141mitogen-activated protein kinase kinase 4, partial
GenPept2135523I38901 JNK-activating protein kinase (EC 2.7.1.-) - human
GenPept15102962Sequence 10 from patent US 6174676
GenPept14477827Sequence 10 from patent US 6136596
GenPept119610382mitogen-activated protein kinase kinase 4, isoform CRA_b
GenPept119610380mitogen-activated protein kinase kinase 4, isoform CRA_b
GenPept1170596MP2K4_HUMAN RecName: Full=Dual specificity mitogen-activated protein kinase kinase 4; Short=MAP kinase kinase 4; Short=MAPKK 4; AltName: Full=JNK-activating kinase 1; AltName: Full=MAPK/ERK kinase 4;
GenPept109113362 PREDICTED: dual specificity mitogen-activated protein kinase kinase 4 isoform 2 [Macaca mulatta]
GenPept60813081mitogen-activated protein kinase kinase 4
GenPept61354993mitogen-activated protein kinase kinase 4
GenPept3249651mitogen-activated protein kinase kinase 1
GenPept791188JNK activating kinase
GenPept756757619Sequence 65 from patent US 8815530
GenPept756521768Sequence 166 from patent US 8741556
GenPept685176MAP kinase kinase 4
GenPept62945793mitogen-activated protein kinase kinase 4
GenPept61357336mitogen-activated protein kinase kinase 4
GenBankAAX41086.1 mitogen-activated protein kinase kinase 4 [synthetic construct]
GenBankAAX36245.1 mitogen-activated protein kinase kinase 4 [synthetic construct]
GenBankEAW89974.1 mitogen-activated protein kinase kinase 4, isoform CRA_b [Homo sapiens]
GenBankEAW89976.1 mitogen-activated protein kinase kinase 4, isoform CRA_b [Homo sapiens]
GenBankAAV38482.1 mitogen-activated protein kinase kinase 4 [Homo sapiens]
GenBankAAC50127.1 JNK activating kinase [Homo sapiens]
GenBankAAC41719.1 MAP kinase kinase 4 [Homo sapiens]
GenBankAAX41373.1 mitogen-activated protein kinase kinase 4 [synthetic construct]
GenBankAAC24130.1 mitogen-activated protein kinase kinase 1 [Homo sapiens]
GenBankAAY22176.1 mitogen-activated protein kinase kinase 4 [Homo sapiens]
ENSEMBLENSP00000262445Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.1.37) (EC 2.7.1.112) (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (S
UCSCGenomeBrowserP45985 
ENSEMBLENSP00000262445 
ENSEMBLENSP00000262445TDI sequence
ENSEMBLENSP00000262445